The incidence of food allergies in western countries has increased dramatically in recent decades.Tolerance to food antigens relies on mucosal CD103+ dendritic cells (DCs), which promote differentiation of regulatory T (Treg) cells.We show that high-fiber feeding in mice improved oral tolerance hp pavilion 15-eg1053cl and protected from food allergy.High-fiber feeding reshaped gut microbial ecology and increased the release of short-chain fatty acids (SCFAs), particularly acetate and butyrate.
High-fiber feeding enhanced oral tolerance and protected against food allergy by enhancing retinal dehydrogenase activity in CD103+ DC.This protection depended on vitamin A in the diet.This feeding regimen also boosted IgA production and enhanced T follicular helper and mucosal germinal center responses.Mice lacking GPR43 or GPR109A, receptors for SCFAs, showed exacerbated food allergy and fewer CD103+ DCs.
Dietary elements, including fiber and arcade smokey the bear belt vitamin A, therefore regulate numerous protective pathways in the gastrointestinal tract, necessary for immune non-responsiveness to food antigens.